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肝衰竭的发病机制极其复杂,近年来趋化因子在病毒性肝炎中的作用逐渐受到广泛关注,大量研究证实,趋化因子的异常表达与病毒性肝炎以及其他类型肝炎的进程密切相关,趋化因子干扰素诱导蛋白-10 (IP-10)可能成为反映肝脏炎性损伤特异性好且敏感的指标.本文就IP-10在不同类型肝损伤发病机制中的研究进展进行综述,为肝损伤的临床诊断、治疗策略和预后评估提供有价值的指标.

The pathogenesis of liver failure is extremely complex. In recent years, the role of chemokines in viral hepatitis has been widely concerned. A large number of studies have confirmed that the abnormal expression of chemokines is closely related to the process of viral hepatitis and other types of hepatitis. Interferon-inducible protein-10 (IP-10) is a good indicator of the specificity and sensitivity of inflammatory liver injury. In this paper, IP-10 in different types of liver injury in the pathogenesis of research progress were reviewed to provide valuable indicators for clinical diagnosis, treatment strategy and prognosis evaluation of liver injury.