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Research progress IL-1β in the mechanism of action and clinical treatment of diabetic retinopathy
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- Author:
- No author available
- Journal Title:
- Chinese Journal of Diabetes
- Issue:
- 7
- DOI:
- 10.3969/j.issn.1006-6187.2024.07.015
- Key Word:
- 白介素1β;糖尿病视网膜病变;作用机制;IL-1β;Diabetic retinopathy;Mechanism of action
Abstract： Diabetic retinopathy(DR)is the main cause of blindness and visual impairment.In hyperglycemia,oxidative stress,or hypoxia,IL-1β upregulation mediates retinal inflammation.Sustained low-grade inflammation can cause retinal vascular damage and neurodegeneration,stimulate oxidative damage,disrupt the blood retinal barrier,and induce retinal neovascularization.This article reviews the research progress of IL-1β in the mechanism and clinical treatment of DR.
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