Objective To explore the effect of locally using dexamethasone on the blood flow velocity in the middle cerebral artery(Fvmca) and cerebral edema after brain injury. Methods 20 rabbits were classified to 2 groups, group A( the control group) and B (the treated group). An experimental rabbit model was conducted to contusion by bone window plasty with extradural hitting. Group B was treated by locally infiltrating of dexamethasone at equidistance to lesions. Group A was given normal saline the same way as Group B. The changes of Fvmca using trans－ cranial Doppler and moisture in brain tissues were observed. Results The normal value of Fvmca was (31.8± 4.5)cm/s, while the value of Fvmca in group A and B were (15.4± 3.9)cm/s and (22.1± 3.5)cm/s separately.Water content in damaged hemisphere in Group A and B were (81.54± 0.55)％ and (79.35± 0.50)％ respectively. There was a significant difference between the 2 groups (P<0.05).The levels of Fvmca in group A and B were lower than that of control and therwas

作者：杨波；徐玉明；张思凤；宋莱俊

来源：现代康复 2001 年 5卷 2期