Role of allogeneic haematopoietic stem cell transplantation in the treatment of adult acute lymphoblastic leukaemia in the era of immunotherapy-临床诊疗知识库

Role of allogeneic haematopoietic stem cell transplantation in the treatment of adult acute lymphoblastic leukaemia in the era of immunotherapy

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作者：

Sun Wei；Huang Xiaojun

来源：

中华医学杂志英文版 2022 年 135卷 8期

标签：

Acute lymphoblastic leukemia Allogeneic hematopoietic stem cell transplantation Immunotherapy Chimeric antigen receptor-T cells Acute lymphoblastic leukemia Allogeneic hematopoietic stem cell transplantation Immunotherapy Chimeric antigen receptor-T cells

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is currently the standard of care for adult acute lymphoblastic leukemia (ALL) patients. In recent years, with the continuous development of immunotherapy, such as chimeric antigen receptor T cells, blinatumomab, and inotuzumab ozogamicin, a series of vital clinical studies have confirmed its high response rate and favorable outcomes for ALL. Although the emergence of immunotherapy has expanded relapsed or refractory (r/r) ALL patients' opportunities to receive allo-HSCT, allo-HSCT is associated with potential challenges. In this review, the role of allo-HSCT in the treatment of adult ALL in the era of immunotherapy will be discussed.

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