Background::Liver biopsy for the diagnosis of non-alcoholic steatohepatitis (NASH) is limited by its inherent invasiveness and possible sampling errors. Some studies have shown that cytokeratin-18 (CK-18) concentrations may be useful in diagnosing NASH, but results across studies have been inconsistent. We aimed to identify the utility of CK-18 M30 concentrations as an alternative to liver biopsy for non-invasive identification of NASH.Methods::Individual data were collected from 14 registry centers on patients with biopsy-proven non-alcoholic fatty liver disease (NAFLD), and in all patients, circulating CK-18 M30 levels were measured. Individuals with a NAFLD activity score (NAS) ≥5 with a score of ≥1 for each of steatosis, ballooning, and lobular inflammation were diagnosed as having definite NASH; individuals with a NAS ≤2 and no fibrosis were diagnosed as having non-alcoholic fatty liver (NAFL).Results::A total of 2571 participants were screened, and 1008 (153 with NAFL and 855 with NASH) were finally

作者：Zhang Huai；Rios Rafael S.；Boursier Jerome；Anty Rodolphe；Chan Wah-Kheong；George Jacob；Yilmaz Yusuf；Wong Vincent Wai-Sun；Fan Jiangao；Dufour Jean-Fran?ois；Papatheodoridis George；Chen Li；Schattenberg J?rn M.；Shi Junping；Xu Liang；Wong Grace Lai-Hung；Lange Naomi F.；Papatheodoridi Margarita；Mi Yuqiang；Zhou Yujie；Byrne Christopher D.；Targher Giovanni；Feng Gong；Zheng Minghua

来源：中华医学杂志英文版 2023 年 136卷 3期